Impact of in vitro HIV infection on human thymic regulatory T cell differentiation.

ABSTRACT:

Background

The differentiation and function of immunosuppressive regulatory T cells (Tregs) is dictated by the master transcription factor FoxP3. During HIV infection, there is an increase in Treg frequencies in the peripheral blood and lymphoid tissues. This accentuates immune dysfunction and disease progression. Expression of FoxP3 by thymic Tregs (tTregs) is partially controlled by TGF-β. This cytokine also contributes to Treg development in the peripheral blood and lymphoid tissues. Although TGF-β mediates lymphoid tissue fibrosis and peripheral Treg differentiation in HIV-infected individuals, its role in the induction and maintenance of Tregs within the thymus during HIV infection remains unclear.

Methods

Thymocytes were isolated from fresh human thymic tissues obtaine

SUBMITTER: Swaminathan S 

PROVIDER: S-EPMC10400333 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature