Being a morning man has causal effects on the cerebral cortex: a Mendelian randomization study.

ABSTRACT:

Introduction

Numerous studies have suggested a connection between circadian rhythm and neurological disorders with cognitive and consciousness impairments in humans, yet little evidence stands for a causal relationship between circadian rhythm and the brain cortex.

Methods

The top 10,000 morningness-related single-nucleotide polymorphisms of the Genome-wide association study (GWAS) summary statistics were used to filter the instrumental variables. GWAS summary statistics from the ENIGMA Consortium were used to assess the causal relationship between morningness and variates like cortical thickness (TH) or surficial area (SA) on the brain cortex. The inverse-variance weighted (IVW) and weighted median (WM) were used as the major estimates whereas MR-Egger, MR Pleiotropy RESidu

SUBMITTER: Yang F 

PROVIDER: S-EPMC10400340 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature