Preservation of mitochondrial membrane potential is necessary for lifespan extension from dietary restriction.

ABSTRACT: Dietary restriction (DR) increases lifespan in many organisms, but its underlying mechanisms are not fully understood. Mitochondria play a central role in metabolic regulation and are known to undergo changes in structure and function in response to DR. Mitochondrial membrane potential (Δψ_m) is the driving force for ATP production and mitochondrial outputs that integrate many cellular signals. One such signal regulated by Δψ_m is nutrient-status sensing. Here, we tested the hypothesis that DR promotes longevity through preserved Δψ_m during adulthood. Using the nematode Caenorhabditis elegans, we find that Δψ_m declines with age relatively early in the lifespan, and this decline is attenuated by DR. Pharmacologic depletion of Δψ_m blocked

SUBMITTER: Berry BJ 

PROVIDER: S-EPMC10400507 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature