Growth hormone receptor (GHR) in AgRP neurons regulates thermogenesis in a sex-specific manner.

ABSTRACT: Evidence for hypothalamic regulation of energy homeostasis and thermoregulation in brown adipose tissue (BAT) during aging has been well recognized, yet the central molecular mediators involved in this process are poorly understood. The arcuate hypothalamus, orexigenic agouti-related peptide (AgRP) neurons control nutrient intake, energy homeostasis, and BAT thermogenesis. To determine the roles of growth hormone receptor (GHR) signaling in the AgRP neurons, we used mice with the AgRP-specific GHR deletion (AgRP^ΔGHR). We found that female AgRP^ΔGHR mice were resistant to temperature adaptation, and their body core temperature remained significantly lower when held at 10 °C, 22 °C, or 30 °C, compared to control mice. Low body core temperature in female AgRP^ΔGHR

SUBMITTER: Stilgenbauer L 

PROVIDER: S-EPMC10400518 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature