Ontology highlight
ABSTRACT:
SUBMITTER: Liaudanskaya V
PROVIDER: S-EPMC10400598 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Liaudanskaya Volha V Fiore Nicholas J NJ Zhang Yang Y Milton Yuka Y Kelly Marilyn F MF Coe Marly M Barreiro Ariana A Rose Victoria K VK Shapiro Matthew R MR Mullis Adam S AS Shevzov-Zebrun Anna A Blurton-Jones Mathew M Whalen Michael J MJ Symes Aviva J AJ Georgakoudi Irene I Nieland Thomas J F TJF Kaplan David L DL
Cell death & disease 20230803 8
Traumatic Brain injury-induced disturbances in mitochondrial fission-and-fusion dynamics have been linked to the onset and propagation of neuroinflammation and neurodegeneration. However, cell-type-specific contributions and crosstalk between neurons, microglia, and astrocytes in mitochondria-driven neurodegeneration after brain injury remain undefined. We developed a human three-dimensional in vitro triculture tissue model of a contusion injury composed of neurons, microglia, and astrocytes and ...[more]