MAVS signaling is required for preventing persistent chikungunya heart infection and chronic vascular tissue inflammation.

ABSTRACT: Chikungunya virus (CHIKV) infection has been associated with severe cardiac manifestations, yet, how CHIKV infection leads to heart disease remains unknown. Here, we leveraged both mouse models and human primary cardiac cells to define the mechanisms of CHIKV heart infection. Using an immunocompetent mouse model of CHIKV infection as well as human primary cardiac cells, we demonstrate that CHIKV directly infects and actively replicates in cardiac fibroblasts. In immunocompetent mice, CHIKV is cleared from cardiac tissue without significant damage through the induction of a local type I interferon response from both infected and non-infected cardiac cells. Using mice deficient in major innate immunity signaling components, we found that signaling through the mitochondrial antiviral-signalin

SUBMITTER: Noval MG 

PROVIDER: S-EPMC10400619 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature