Gata3 is required in late proneurosensory development for proper sensory cell formation and organization.

ABSTRACT: It has previously been shown that the zinc-finger transcription factor Gata3 has dynamic expression within the inner ear throughout embryonic development and is essential for cochlear neurosensory development. However, the temporal window for which Gata3 is required for proper formation of the cochlear neurosensory epithelia remains unclear. To investigate the role of Gata3 in cochlear neurosensory development in the late prosensory stages, we used the Sox2-cre^ERT2 mouse line to target and conditionally delete Gata3 at E11.5, a timepoint before cells have fully committed to a neurosensory fate. While the inner ears of Sox2-cre^ERT2: Gata3 f/f mice appear normal with no gross structural defects, the sensory cells in the organ of Corti are partially lost and disorganized

SUBMITTER: Blinkiewicz PV 

PROVIDER: S-EPMC10400699 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature