Gene expression signatures associated with chronic endometritis revealed by RNA sequencing.

ABSTRACT:

Introduction

Chronic endometritis (CE) is a persistent inflammatory condition of the endometrium characterized by the infiltration of plasma cells in the endometrial stroma. CD138 immunohistochemistry is considered to improve the CE diagnosis rate.

Methods

Using the number of CD138-positive cells equal or greater than five as a diagnostic criterion for CE, we identified 24 CE and 33 non-CE cases among women with infertility. We conducted RNA-sequencing analysis for these 57 cases in total as an attempt to elucidate the molecular pathogenesis of CE and to search for new biomarkers for CE.

Results and discussion

By comparing CE and non-CE groups, we identified 20 genes upregulated in the endometria of CE patients, including 12 immunoglobulin-related genes and eight non-

SUBMITTER: Oshina K 

PROVIDER: S-EPMC10400718 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature