Mapping tissue microstructure across the human brain on a clinical scanner with soma and neurite density image metrics.

ABSTRACT: Soma and neurite density image (SANDI) is an advanced diffusion magnetic resonance imaging biophysical signal model devised to probe in vivo microstructural information in the gray matter (GM). This model requires acquisitions that include b values that are at least six times higher than those used in clinical practice. Such high b values are required to disentangle the signal contribution of water diffusing in soma from that diffusing in neurites and extracellular space, while keeping the diffusion time as short as possible to minimize potential bias due to water exchange. These requirements have limited the use of SANDI only to preclinical or cutting-edge human scanners. Here, we investigate the potential impact of neglecting water exchange in the SANDI model and present a 10-min acquisi

SUBMITTER: Schiavi S 

PROVIDER: S-EPMC10400787 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature