Multi-scale structural alterations of the thalamus and basal ganglia in focal epilepsy using 7T MRI.

ABSTRACT: Focal epilepsy is characterized by repeated spontaneous seizures that originate from cortical epileptogenic zone networks (EZN). Analysis of intracerebral recordings showed that subcortical structures, and in particular the thalamus, play an important role in seizure dynamics as well, supporting their structural alterations reported in the neuroimaging literature. Nonetheless, between-patient differences in EZN localization (e.g., temporal vs. non-temporal lobe epilepsy) as well as extension (i.e., number of epileptogenic regions) might impact the magnitude as well as spatial distribution of subcortical structural changes. Here we used 7 Tesla MRI T₁ data to provide an unprecedented description of subcortical morphological (volume, tissue deformation, and shape) and longitudinal

SUBMITTER: Haast RAM 

PROVIDER: S-EPMC10400791 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature