IMOPAC: A web server for interactive multiomics and pharmacological analyses of patient-derived cancer cell lines.

ABSTRACT: Large-scale multidimensional cancer genomic and pharmacological profiles have been created by several large consortium projects, including NCI-60, GDSC and DepMap, providing novel opportunities for data mining and further understanding of intrinsic therapeutic response mechanisms. However, it is increasingly challenging for experimental biologists, especially those without a bioinformatic background, to integrate, explore, and analyse these tremendous pharmacogenomics. To address this gap, IMOPAC, an interactive and easy-to-use web-based tool, was introduced to provide rapid visualizations and customizable functionalities on the basis of these three publicly available databases, which may reduce pharmacogenomic profiles from cell lines into readily understandable genetic, epigenetic, trans

SUBMITTER: Li G 

PROVIDER: S-EPMC10400808 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature