A conserved 3D pattern in a Streptococcus pyogenes M protein immunogen elicits M-type crossreactivity.

ABSTRACT: Coiled coil-forming M proteins of the widespread and potentially deadly bacterial pathogen Streptococcus pyogenes (strep A) are immunodominant targets of opsonizing antibodies. However, antigenic sequence variability of M proteins into >220 M types, as defined by their hypervariable regions (HVRs), is considered to limit M proteins as vaccine immunogens because of type specificity in the antibody response. Surprisingly, a multi-HVR immunogen in clinical vaccine trials was shown to elicit M-type crossreactivity. The basis for this crossreactivity is unknown but may be due in part to antibody recognition of a 3D pattern conserved in many M protein HVRs that confers binding to human complement C4b-binding protein (C4BP). To test this hypothesis, we investigated whether a single M protein immu

SUBMITTER: Wang KC 

PROVIDER: S-EPMC10400905 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature