Targeted and selective knockout of the TLQP-21 neuropeptide unmasks its unique role in energy homeostasis.

ABSTRACT:

Objective

Pro-peptide precursors are processed into biologically active peptide hormones or neurotransmitters, each playing an essential role in physiology and disease. Genetic loss of function of a pro-peptide precursor results in the simultaneous ablation of all biologically-active peptides within that precursor, often leading to a composite phenotype that can be difficult to align with the loss of specific peptide components. Due to this biological constraint and technical limitations, mice carrying the selective ablation of individual peptides encoded by pro-peptide precursor genes, while leaving the other peptides unaffected, have remained largely unaddressed.

Methods

We developed and characterized a mouse model carrying the selective knockout of the TLQP-21 neuropeptid

SUBMITTER: Sahu BS 

PROVIDER: S-EPMC10400922 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature