Social memory in female mice is rapidly modulated by 17β-estradiol through ERK and Akt modulation of synapse formation.

ABSTRACT: Social memory is essential to the functioning of a social animal within a group. Estrogens can affect social memory too quickly for classical genomic mechanisms. Previously, 17β-estradiol (E2) rapidly facilitated short-term social memory and increased nascent synapse formation, these synapses being potentiated following neuronal activity. However, what mechanisms underlie and coordinate the rapid facilitation of social memory and synaptogenesis are unclear. Here, the necessity of extracellular signal-regulated kinase (ERK) and phosphoinositide 3-kinase (PI3K) signaling for rapid facilitation of short-term social memory and synaptogenesis was tested. Mice performed a short-term social memory task or were used as task-naïve controls. ERK and PI3K pathway inhibitors were infused intradorsal h

SUBMITTER: Sheppard PAS 

PROVIDER: S-EPMC10400940 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature