The helicase-like transcription factor redirects the autophagic flux and restricts human T cell leukemia virus type 1 infection.

ABSTRACT: Retroviruses and their host have coevolved in a delicate balance between viral replication and survival of the infected cell. In this equilibrium, restriction factors expressed by infected cells control different steps of retroviral replication such as entry, uncoating, nuclear import, expression, or budding. Here, we describe a mechanism of restriction against human T cell leukemia virus type 1 (HTLV-1) by the helicase-like transcription factor (HLTF). We show that RNA and protein levels of HLTF are reduced in primary T cells of HTLV-1-infected subjects, suggesting a clinical relevance. We further demonstrate that the viral oncogene Tax represses HLTF transcription via the Enhancer of zeste homolog 2 methyltransferase of the Polycomb repressive complex 2. The Tax protein also directly int

SUBMITTER: Beauvois A 

PROVIDER: S-EPMC10400947 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature