A tissue chip with integrated digital immunosensors: In situ brain endothelial barrier cytokine secretion monitoring.

ABSTRACT: Organ-on-a-chip platforms have potential to offer more cost-effective, ethical, and human-resembling models than animal models for disease study and drug discovery. Particularly, the Blood-Brain-Barrier-on-a-chip (BBB-oC) has emerged as a promising tool to investigate several neurological disorders since it promises to provide a model of the multifunctional tissue working as an important node to control pathogen entry, drug delivery and neuroinflammation. A comprehensive understanding of the multiple physiological functions of the tissue model requires biosensors detecting several tissue-secreted substances in a BBB-oC system. However, current sensor-integrated BBB-oC platforms are only available for tissue membrane integrity characterization based on permeability measurement. Protein secr

SUBMITTER: Su SH 

PROVIDER: S-EPMC10401069 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature