The effects of AQP4 rs162009 on resting-state brain activity in Parkinson's disease.

ABSTRACT:

Background

We previously identified a significant association between Aquaporin-4 (AQP4) and Parkinson's disease (PD).

Objectives

To identify whether AQP4 single-nucleotide polymorphism (SNP) rs162009 affects regional brain activity and clinical phenotypes of PD.

Methods

Low-frequency fluctuation amplitude (ALFF) was used to evaluate spontaneous brain activity, regional homogeneity (ReHo) was used to evaluate the pace of activity of adjacent voxel regions, and degree centrality (DC) was used to describe the functional connection strength between a voxel and the whole brain. Disease severity and PD stage were assessed with the Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale and Hoehn and Yahr scales, and the Montreal Cogniti

SUBMITTER: Jiang M 

PROVIDER: S-EPMC10401089 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature