Neuropharmacological insight into preventive intervention in posttraumatic epilepsy based on regulating glutamate homeostasis.

ABSTRACT:

Background

Posttraumatic epilepsy (PTE) is one of the most critical complications of traumatic brain injury (TBI), significantly increasing TBI patients' neuropsychiatric symptoms and mortality. The abnormal accumulation of glutamate caused by TBI and its secondary excitotoxicity are essential reasons for neural network reorganization and functional neural plasticity changes, contributing to the occurrence and development of PTE. Restoring glutamate balance in the early stage of TBI is expected to play a neuroprotective role and reduce the risk of PTE.

Aims

To provide a neuropharmacological insight for drug development to prevent PTE based on regulating glutamate homeostasis.

Methods

We discussed how TBI affects glutamate homeostasis and its relationship with PTE. Fur

SUBMITTER: Gao Y 

PROVIDER: S-EPMC10401093 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature