Association of dysphagia with altered brain glucose metabolism in Parkinson's disease.

ABSTRACT:

Aims

Dysphagia is a major clinical concern in Parkinson's disease (PD). However, the relationship between the development of phase-specific dysphagia and the regional brain glucose metabolism remains unclear. Our objective was to investigate the distributions of brain glucose metabolism specific to oral and pharyngeal phases of dysphagia in PD.

Methods

In this retrospective cross-sectional study, patients with PD who underwent videofluoroscopic swallowing study (VFSS) and ¹⁸ F-fluorodeoxy-glucose positron emission tomography at intervals of <1 month were included. Each swallow was assessed by the binarized Videofluoroscopic Dysphagia Scale with 14 subitems, seven each for the oral and pharyngeal phases. Metabolism mapping was performed by superimposing significant

SUBMITTER: Oh JY 

PROVIDER: S-EPMC10401099 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature