Ameliorating Mitochondrial Dysfunction of Neurons by Biomimetic Targeting Nanoparticles Mediated Mitochondrial Biogenesis to Boost the Therapy of Parkinson's Disease.

ABSTRACT: Mitochondrial dysfunction of neurons is the core pathogenesis of incurable Parkinson's disease (PD). It is crucial to ameliorate the mitochondrial dysfunction of neurons for boosting the therapy of PD. Herein, the remarkable promotion of mitochondrial biogenesis to ameliorate mitochondrial dysfunction of neurons and improve the treatment of PD by using mitochondria-targeted biomimetic nanoparticles, which are Cu_{2- x} Se-based nanoparticles functionalized with curcumin and wrapped with DSPE-PEG₂₀₀₀ -TPP-modified macrophage membrane (denoted as CSCCT NPs), is reported. These nanoparticles can efficiently target mitochondria of damaged neurons in an inflammatory environment, and mediate the signaling pathway of NAD⁺ /SIRT1/PGC-1α/PPARγ/NRF1/TFAM to a

SUBMITTER: Zheng Q 

PROVIDER: S-EPMC10401119 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature