Cortical dopamine D5 receptors regulate neuronal circuit oscillatory activity and memory in rats.

ABSTRACT:

Introduction

The dopamine D5 receptor (D5R) shows high expression in cortical regions, yet the role of the receptor in learning and memory remains poorly understood. This study evaluated the impact of prefrontal cortical (PFC) D5R knockdown in rats on learning and memory and assessed the role of the D5R in the regulation of neuronal oscillatory activity and glycogen synthase kinase-3 (GSK-3β), processes integral to cognitive function.

Materials and methods

Using an adeno-associated viral (AAV) vector, male rats were infused with shRNA to the D5R bilaterally into the PFC. Local field potential recordings were taken from freely moving animals and spectral power and coherence were evaluated in, and between, the PFC, orbitofrontal cortex (OFC), hippocampus (HIP), and thalamus. A

SUBMITTER: Albeely AM 

PROVIDER: S-EPMC10401150 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature