Multiparametric Immunoimaging Maps Inflammatory Signatures in Murine Myocardial Infarction Models.

ABSTRACT: In the past 2 decades, research on atherosclerotic cardiovascular disease has uncovered inflammation to be a key driver of the pathophysiological process. A pressing need therefore exists to quantitatively and longitudinally probe inflammation, in preclinical models and in cardiovascular disease patients, ideally using non-invasive methods and at multiple levels. Here, we developed and employed in vivo multiparametric imaging approaches to investigate the immune response following myocardial infarction. The myocardial infarction models encompassed either transient or permanent left anterior descending coronary artery occlusion in C57BL/6 and Apoe^-/-mice. We performed nanotracer-based fluorine magnetic resonance imaging and positron emission tomography (PET) imaging using

SUBMITTER: Maier A 

PROVIDER: S-EPMC10401290 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature