Human retinal secretome: A cross-link between mesenchymal and retinal cells.

ABSTRACT: In recent years, mesenchymal stem cells (MSC) have been considered the most effective source for regenerative medicine, especially due to released soluble paracrine bioactive components and extracellular vesicles. These factors, collectively called the secretome, play crucial roles in immunomodulation and in improving survival and regeneration capabilities of injured tissue. Recently, there has been a growing interest in the secretome released by retinal cytotypes, especially retinal pigment epithelium and Müller glia cells. The latter trophic factors represent the key to preserving morphofunctional integrity of the retina, regulating biological pathways involved in survival, function and responding to injury. Furthermore, these factors can play a pivotal role in onset and progression of r

SUBMITTER: Donato L 

PROVIDER: S-EPMC10401416 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature