Neural stem cells for Parkinson's disease management: Challenges, nanobased support, and prospects.

ABSTRACT: Parkinson's disease (PD), characterized by loss of nigrostriatal dopaminergic neurons, is one of the most predominant neurodegenerative diseases affecting the elderly population worldwide. The concept of stem cell therapy in managing neurodegenerative diseases has evolved over the years and has recently rapidly progressed. Neural stem cells (NSCs) have a few key features, including self-renewal, proliferation, and multipotency, which make them a promising agent targeting neurodegeneration. It is generally agreed that challenges for NSC-based therapy are present at every stage of the transplantation process, including preoperative cell preparation and quality control, perioperative procedures, and postoperative graft preservation, adherence, and overall therapy success. In this review, we p

SUBMITTER: Oz T 

PROVIDER: S-EPMC10401423 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature