Analysis of N6-methyladenosine-modified mRNAs in diabetic cataract.

ABSTRACT:

Background

Cataracts remain a prime reason for visual disturbance and blindness all over the world, despite the capacity for successful surgical replacement with artificial lenses. Diabetic cataract (DC), a metabolic complication, usually occurs at an earlier age and progresses faster than age-related cataracts. Evidence has linked N6-methyladenosine (m6A) to DC progression. However, there exists a lack of understanding regarding RNA m6A modifications and the role of m6A in DC pathogenesis.

Aim

To elucidate the role played by altered m6A and differentially expressed mRNAs (DEmRNAs) in DC.

Methods

Anterior lens capsules were collected from the control subjects and patients with DC. M6A epitranscriptomic microarray was performed to investigate the altered m6A modificati

SUBMITTER: Cai L 

PROVIDER: S-EPMC10401451 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature