Application of G-quadruplex targets in gastrointestinal cancers: Advancements, challenges and prospects.

ABSTRACT: Genomic instability and inflammation are considered to be two enabling characteristics that support cancer development and progression. G-quadruplex structure is a key element that contributes to genomic instability and inflammation. G-quadruplexes were once regarded as simply an obstacle that can block the transcription of oncogenes. A ligand targeting G-quadruplexes was found to have anticancer activity, making G-quadruplexes potential anticancer targets. However, further investigation has revealed that G-quadruplexes are widely distributed throughout the human genome and have many functions, such as regulating DNA replication, DNA repair, transcription, translation, epigenetics, and inflammatory response. G-quadruplexes play double regulatory roles in transcription and translation. In t

SUBMITTER: Han ZQ 

PROVIDER: S-EPMC10401460 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature