Cachexia causes time-dependent activation of the inflammasome in the liver.

ABSTRACT:

Background

Cachexia is a wasting syndrome associated with systemic inflammation and metabolic disruption. Detection of the early signs of the disease may contribute to the effective attenuation of associated symptoms. Despite playing a central role in the control of metabolism and inflammation, the liver has received little attention in cachexia. We previously described relevant disruption of metabolic pathways in the organ in an animal model of cachexia, and herein, we adopt the same model to investigate temporal onset of inflammation in the liver. The aim was thus to study inflammation in rodent liver in the well-characterized cachexia model of Walker 256 carcinosarcoma and, in addition, to describe inflammatory alterations in the liver of one cachectic colon cancer patient, as c

SUBMITTER: das Neves RX 

PROVIDER: S-EPMC10401524 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature