Iron deficiency is related to lower muscle mass in community-dwelling individuals and impairs myoblast proliferation.

ABSTRACT:

Background

Loss of muscle mass is linked with impaired quality of life and an increased risk of morbidity and premature mortality. Iron is essential for cellular processes such as energy metabolism, nucleotide synthesis and numerous enzymatic reactions. As the effects of iron deficiency (ID) on muscle mass and function are largely unknown, we aimed to assess the relation between ID and muscle mass in a large population-based cohort, and subsequently studied effects of ID on cultured skeletal myoblasts and differentiated myocytes.

Methods

In a population-based cohort of 8592 adults, iron status was assessed by plasma ferritin and transferrin saturation, and muscle mass was estimated using 24-h urinary creatinine excretion rate (CER). The relationships of ferritin and transfer

SUBMITTER: Vinke JSJ 

PROVIDER: S-EPMC10401536 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature