Skeletal muscle analysis of cancer patients reveals a potential role for carnosine in muscle wasting.

ABSTRACT:

Background

Muscle wasting during cancer cachexia is mediated by protein degradation via autophagy and ubiquitin-linked proteolysis. These processes are sensitive to changes in intracellular pH ([pH]_i ) and reactive oxygen species, which in skeletal muscle are partly regulated by histidyl dipeptides, such as carnosine. These dipeptides, synthesized by the enzyme carnosine synthase (CARNS), remove lipid peroxidation-derived aldehydes, and buffer [pH]_i . Nevertheless, their role in muscle wasting has not been studied.

Methods

Histidyl dipeptides in the rectus abdominis (RA) muscle and red blood cells (RBCs) of male and female controls (n = 37), weight stable (WS: n = 35), and weight losing (WL; n = 30) upper gastrointestinal cancer (UGIC) patients, were pr

SUBMITTER: Posa DK 

PROVIDER: S-EPMC10401540 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature