The Partial M₁ Muscarinic Cholinergic Receptor Agonist, CDD-0102A, Differentially Modulates Glutamate Efflux in Striatal Subregions during Stereotyped Motor Behavior in the BTBR Mouse Model of Autism.

ABSTRACT: The BTBR T⁺ Itpr3^tf/J (BTBR) mouse displays elevated repetitive motor behaviors. Treatment with the partial M₁ muscarinic receptor agonist, CDD-0102A, attenuates stereotyped motor behaviors in BTBR mice. The present experiment investigated whether CDD-0102A modifies changes in striatal glutamate concentrations during stereotyped motor behavior in BTBR and B6 mice. Using glutamate biosensors, change in striatal glutamate efflux was measured during bouts of digging and grooming behavior with a 1 s time resolution. Mice displayed both decreases and increases in glutamate efflux during such behaviors. Magnitude of changes in glutamate efflux (decreases and increases) from dorsomedial and dorsolateral striatum were significantly greater in BTBR mice compared to

SUBMITTER: Teneqexhi P 

PROVIDER: S-EPMC10401636 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature