Reactivity of [(PNP)Mn(CO)₂] with Organophosphates.

ABSTRACT: Organophosphorus nerve agents (OPAs) are a toxic class of synthetic compounds that cause adverse effects with many biological systems. Development of methods for environmental remediation and passivation has been ongoing for years. However, little progress has been made in therapeutic development for exposure victims. Given the postexposure behavior of OPA materials in enzymes such as acetylcholinesterase (AChE), development of electrophilic compounds as therapeutics may be more beneficial than the currently employed nucleophilic countermeasures. In this report, we present our studies with an electrophilic, 16-electron manganese complex (^iPrPNP)Mn(CO)₂ (1) and the nucleophilic hydroxide derivative (^iPrPN^HP)Mn(CO)₂(

SUBMITTER: Livesay BN 

PROVIDER: S-EPMC10401673 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature