Polygenicity of Comorbid Depression in Multiple Sclerosis.

ABSTRACT:

Background and objectives

Depression is common in multiple sclerosis (MS) and is associated with faster disability progression. The etiology of comorbid depression in MS remains poorly understood. Identification of individuals with a high risk of depression, through polygenic scores (PGS), may facilitate earlier identification. Previous genetic studies of depression considered depression as a primary disorder, not a comorbidity, and thus, findings may not generalize to MS. Body mass index (BMI) is a risk factor of both MS and depression, and its association may highlight differences in depression in MS. To improve the understanding of comorbid depression in MS, we will investigate PGS in people with MS, with the hypothesis that a higher depression PGS is associated with increased o

SUBMITTER: Kowalec K 

PROVIDER: S-EPMC10401690 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature