Development of muscle weakness in a mouse model of critical illness: does fibroblast growth factor 21 play a role?

ABSTRACT:

Background

Critical illness is hallmarked by severe stress and organ damage. Fibroblast growth factor 21 (FGF21) has been shown to rise during critical illness. FGF21 is a pleiotropic hormone that mediates adaptive responses to tissue injury and repair in various chronic pathological conditions. Animal studies have suggested that the critical illness-induced rise in FGF21 may to a certain extent protect against acute lung, liver, kidney and brain injury. However, FGF21 has also been shown to mediate fasting-induced loss of muscle mass and force. Such loss of muscle mass and force is a frequent problem of critically ill patients, associated with adverse outcome. In the present study, we therefore investigated whether the critical illness-induced acute rise in FGF21 is muscle-protect

SUBMITTER: Vankrunkelsven W 

PROVIDER: S-EPMC10401744 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature