Characterization of a strain-specific CD-1 reference genome reveals potential inter- and intra-strain functional variability.

ABSTRACT:

Background

CD-1 is an outbred mouse stock that is frequently used in toxicology, pharmacology, and fundamental biomedical research. Although inbred strains are typically better suited for such studies due to minimal genetic variability, outbred stocks confer practical advantages over inbred strains, such as improved breeding performance and low cost. Knowledge of the full genetic variability of CD-1 would make it more useful in toxicology, pharmacology, and fundamental biomedical research.

Results

We performed deep genomic DNA sequencing of CD-1 mice and used the data to identify genome-wide SNPs, indels, and germline transposable elements relative to the mm10 reference genome. We used multiple genome-wide sequencing data types and previously published CD-1 SNPs to validate

SUBMITTER: Jung YH 

PROVIDER: S-EPMC10401811 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature