Molecular characterization of colorectal adenoma and colorectal cancer via integrated genomic transcriptomic analysis.

ABSTRACT:

Introduction

Colorectal adenoma can develop into colorectal cancer. Determining the risk of tumorigenesis in colorectal adenoma would be critical for avoiding the development of colorectal cancer; however, genomic features that could help predict the risk of tumorigenesis remain uncertain.

Methods

In this work, DNA and RNA parallel capture sequencing data covering 519 genes from colorectal adenoma and colorectal cancer samples were collected. The somatic mutation profiles were obtained from DNA sequencing data, and the expression profiles were obtained from RNA sequencing data.

Results

Despite some similarities between the adenoma samples and the cancer samples, different mutation frequencies, co-occurrences, and mutually exclusive patterns were detected in the mutati

SUBMITTER: Pan P 

PROVIDER: S-EPMC10401844 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature