Lysosome blockade induces divergent metabolic programs in macrophages and tumours for cancer immunotherapy.

ABSTRACT:

Background

Platinum-drugs based chemotherapy in clinic increases the potency of tumor cells to produce M2 macrophages, thus leading to poor anti-metastatic activity and immunosuppression. Lysosome metabolism is critical for cancer cell migration and invasion, but how it promotes antitumor immunity in tumours and macrophages is poorly understood and the underlying mechanisms are elusive. The present study aimed to explore a synergistic strategy to dismantle the immunosuppressive microenvironment of tumours and metallodrugs discovery by using the herent metabolic plasticity.

Methods

Naphplatin was prepared by coordinating an active alkaline moiety to cisplatin, which can regulate the lysosomal functions. Colorectal carcinoma cells were selected to perform the in vivo biologica

SUBMITTER: Ma J 

PROVIDER: S-EPMC10401909 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature