Metabolomic rearrangement controls the intrinsic microbial response to temperature changes.

ABSTRACT: Temperature is one of the key determinants of microbial behavior and survival, whose impact is typically studied under heat- or cold-shock conditions that elicit specific regulation to combat lethal stress. At intermediate temperatures, cellular growth rate varies according to the Arrhenius law of thermodynamics without stress responses, a behavior whose origins have not yet been elucidated. Using single-cell microscopy during temperature perturbations, we show that bacteria exhibit a highly conserved, gradual response to temperature upshifts with a time scale of ~1.5 doublings at the higher temperature, regardless of initial/final temperature or nutrient source. We find that this behavior is coupled to a temperature memory, which we rule out as being neither transcriptional, translational

SUBMITTER: Knapp BD 

PROVIDER: S-EPMC10401945 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature