Activation of the Aryl Hydrocarbon Receptor in Endothelial Cells Impairs Ischemic Angiogenesis in Chronic Kidney Disease.

ABSTRACT:

Rationale

Chronic kidney disease (CKD) is a strong risk factor for peripheral artery disease (PAD) that is associated with worsened clinical outcomes. CKD leads to accumulation of tryptophan metabolites that associate with adverse limb events in PAD and are ligands of the aryl hydrocarbon receptor (AHR) which may regulate ischemic angiogenesis.

Objectives

To test if endothelial cell-specific deletion of the AHR (AHR^ecKO) alters ischemic angiogenesis and limb function in mice with CKD subjected to femoral artery ligation.

Findings

Male AHR^ecKO mice with CKD displayed better limb perfusion recovery and enhanced ischemic angiogenesis compared to wildtype mice with CKD. However, the improved limb perfusion did not result in better muscle performance.

SUBMITTER: Palzkill VR 

PROVIDER: S-EPMC10401998 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature