E-cadherin biointerfaces reprogram collective cell migration and cell cycling by forcing homeostatic conditions.

ABSTRACT: Cells attach to the world around them in two ways-cell:extracellular-matrix adhesion and cell:cell adhesion-and conventional biomaterials are made to resemble the matrix to encourage integrin-based cell adhesion. However, interest is growing for cell-mimetic interfaces that mimic cell-cell interactions using cadherin proteins, as this offers a new way to program cell behavior and design synthetic implants and objects that can integrate directly into living tissues. Here, we explore how these cadherin-based materials affect collective cell behaviors, focusing specifically on collective migration and cell cycle regulation in cm-scale epithelia. We built culture substrates where half of the culture area was functionalized with matrix proteins and the contiguous half was functionalized with E-

SUBMITTER: Suh K 

PROVIDER: S-EPMC10402016 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature