TGF-β broadly modifies rather than specifically suppresses reactivated memory CD8 T cells in a dose-dependent manner.

ABSTRACT: Transforming growth factor β (TGF-β) directly acts on naïve, effector and memory T cells to control cell fate decisions, which was shown using genetic abrogation of TGF-β signaling. TGF-β availability is altered by infections and cancer, however the dose-dependent effects of TGF-β on memory CD8 T cell (T_mem) reactivation are still poorly defined. We examined how activation and TGF-β signals interact to shape the functional outcome of T_mem reactivation. We found that TGF-β could suppress cytotoxicity in a manner that was inversely proportional to the strength of the activating TCR or pro-inflammatory signals. In contrast, even high doses of TGF-β had a comparatively modest effect on IFN-γ expression in the context of weak and strong reactivation signals. Since CD8 T

SUBMITTER: Taber A 

PROVIDER: S-EPMC10402134 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature