Bacterial pathogens deliver water/solute-permeable channels as a virulence strategy.

ABSTRACT: Many animal and plant pathogenic bacteria utilize a type III secretion system to deliver effector proteins into the host cell ^1,2 . Elucidation of how these effector proteins function in the host cell is critical for understanding infectious diseases in animals and plants ^3-5 . The widely conserved AvrE/DspE-family effectors play a central role in the pathogenesis of diverse phytopathogenic bacteria ⁶ . These conserved effectors are involved in the induction of "water-soaking" and host cell death that are conducive to bacterial multiplication in infected tissues. However, the exact biochemical functions of AvrE/DspE-family effectors have been recalcitrant to mechanistic understanding for three decades. Here we show that AvrE/DspE-family effectors fold into

SUBMITTER: Nomura K 

PROVIDER: S-EPMC10402153 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature