Ontology highlight
ABSTRACT:
SUBMITTER: Hafer TL
PROVIDER: S-EPMC10402164 | biostudies-literature | 2023 Jul
REPOSITORIES: biostudies-literature
bioRxiv : the preprint server for biology 20230728
We sought to explore the hypothesis that host factors required for HIV-1 replication also play a role in latency reversal. Using a CRISPR gene library of putative HIV dependency factors, we performed a screen to identify genes required for latency reactivation. We identified several HIV-1 dependency factors that play a key role in HIV-1 latency reactivation including <i>ELL</i> , <i>UBE2M</i> , <i>TBL1XR1</i> , <i>HDAC3</i> , <i>AMBRA1</i> , and <i>ALYREF</i> . Knockout of Cyclin T1 ( <i>CCNT1</ ...[more]