Sex, gender diversity, and brain structure in children ages 9 to 11 years old.

ABSTRACT: There remains little consensus about the relationship between sex and brain structure, particularly in childhood. Moreover, few pediatric neuroimaging studies have analyzed both sex and gender as variables of interest - many of which included small sample sizes and relied on binary definitions of gender. The current study examined gender diversity with a continuous felt-gender score and categorized sex based on X and Y allele frequency in a large sample of children ages 9-11 years-old (N=7693). Then, a statistical model-building approach was employed to determine whether gender diversity and sex independently or jointly relate to brain morphology, including subcortical volume, cortical thickness, gyrification, and white matter microstructure. The model with sex, but not gender diversity, w

SUBMITTER: Torgerson C 

PROVIDER: S-EPMC10402171 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature