Protocol and statistical analysis plan for the Mode of Ventilation During Critical IllnEss (MODE) trial.

ABSTRACT:

Introduction

For every critically ill adult receiving invasive mechanical ventilation, clinicians must select a mode of ventilation. The mode of ventilation determines whether the ventilator directly controls the tidal volume or the inspiratory pressure. Newer hybrid modes allow clinicians to set a target tidal volume, for which the ventilator controls and adjusts the inspiratory pressure. A strategy of low tidal volumes and low plateau pressure improves outcomes, but the optimal mode to achieve these targets is not known.

Methods and analysis

The Mode of Ventilation During Critical Illness (MODE) trial is a cluster-randomized, multiple-crossover pilot trial being conducted in the medical intensive care unit (ICU) at an academic center. The MODE trial compares the use of vol

SUBMITTER: Seitz KP 

PROVIDER: S-EPMC10402229 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature