Vascular injury markers associated with cognitive impairment in people with HIV on suppressive antiretroviral therapy.

ABSTRACT:

Objective

Human immunodeficiency virus (HIV)-associated neurocognitive disorders (HAND) remain prevalent despite viral suppression on antiretroviral therapy (ART). Vascular disease contributes to HAND, but peripheral markers that distinguish vascular cognitive impairment (VCI) from HIV-related etiologies remain unclear.

Design

Cross-sectional study of vascular injury, inflammation, and central nervous system (CNS) injury markers in relation to HAND.

Methods

Vascular injury (VCAM-1, ICAM-1, CRP), inflammation (IFN-γ, IL-1β, IL-6, IL-8, IL-15, IP-10, MCP-1, VEGF-A), and CNS injury (NFL, total Tau, GFAP, YKL-40) markers were measured in plasma and CSF from 248 individuals (143 HIV+ on suppressive ART and 105 HIV- controls).

Results

Median age was 53 years, median

SUBMITTER: Guha D 

PROVIDER: S-EPMC10402231 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature