Characterization of Circulating Fibrocytes in People Living with HIV on Stable Antiretroviral Therapy.

ABSTRACT: Highly effective combination antiretroviral therapy has reduced HIV infection to a manageable chronic disease, shifting the clinical landscape toward management of noninfectious comorbidities in people living with HIV (PLWH). These comorbidities are diverse, generally associated with accelerated aging, and present within multiple organ systems. Mechanistically, immune dysregulation and chronic inflammation, both of which persist in PLWH with well-controlled virally suppressive HIV infection, are suggested to create and exacerbate noninfectious comorbidity development. Persistent inflammation often leads to fibrosis, which is the common end point pathologic feature associated with most comorbidities. Fibrocytes are bone marrow-derived fibroblast-like cells, which emerged as key effector cel

SUBMITTER: Dean LS 

PROVIDER: S-EPMC10402248 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature