Adenosine pathway regulates inflammation during Plasmodium vivax infection.

ABSTRACT:

Background

Plasmodium spp. infection triggers the production of inflammatory cytokines that are essential for parasite control, and conversely responsible for symptoms of malaria. Monocytes play a role in host defense against Plasmodium vivax infection and represent the main source of inflammatory cytokines and reactive oxygen species. The anti-inflammatory cytokine IL-10 is a key regulator preventing exacerbated inflammatory responses. Studies suggested that different clinical presentations of malaria are strongly associated with an imbalance in the production of inflammatory and anti-inflammatory cytokines.

Methods

A convenience sampling of peripheral blood mononuclear cells from Plasmodium vivax-infected patients and healthy donors were tested for the

SUBMITTER: Diniz SQ 

PROVIDER: S-EPMC10402272 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature