Ambient air pollution during pregnancy and DNA methylation in umbilical cord blood, with potential mediation of associations with infant adiposity: The Healthy Start study.

ABSTRACT:

Background

Prenatal exposure to ambient air pollution has been associated with adverse offspring health outcomes. Childhood health effects of prenatal exposures may be mediated through changes to DNA methylation detectable at birth.

Methods

Among 429 non-smoking women in a cohort study of mother-infant pairs in Colorado, USA, we estimated associations between prenatal exposure to ambient fine particulate matter (PM_2.5) and ozone (O₃), and epigenome-wide DNA methylation of umbilical cord blood cells at delivery (2010-2014). We calculated average PM_2.5 and O₃ in each trimester of pregnancy and the full pregnancy using inverse-distance-weighted interpolation. We fit linear regression models adjusted for potential confounders and cell

SUBMITTER: Starling AP 

PROVIDER: S-EPMC10402394 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature