Associations of miRNA-146a and miRNA-223 with Rheumatoid Arthritis and Their Predictive Values.

ABSTRACT:

Purpose

To analyze the independent associations of miRNA-146a and miRNA-223 with rheumatoid arthritis (RA) and evaluate their predictive values for RA.

Patients and methods

A total of 68 RA patients were selected as cases, and meanwhile 68 patients with a traumatic knee condition were selected as controls by matching to the cases according to sex and age at the ratio of 1:1. The independent associations of miRNA-146a and miRNA-223 with RA were identified by binary logistic regression analysis. Receiver operating characteristic (ROC) curve was used to evaluate their predictive values for RA.

Results

MiRNA-146a and miRNA-223 expression levels in both synovial tissues and serums were statistically higher in cases than in controls, and their expression levels in se

SUBMITTER: Zhang H 

PROVIDER: S-EPMC10402887 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature