Repeated hippocampal seizures lead to brain-wide reorganization of circuits and seizure propagation pathways.

ABSTRACT: Repeated seizure activity can lead to long-term changes in seizure dynamics and behavior. However, resulting changes in brain-wide dynamics remain poorly understood. This is due partly to technical challenges in precise seizure control and in vivo whole-brain mapping of circuit dynamics. Here, we developed an optogenetic kindling model through repeated stimulation of ventral hippocampal CaMKII neurons in adult rats. We then combined fMRI with electrophysiology to track brain-wide circuit dynamics resulting from non-afterdischarge (AD)-generating stimulations and individual convulsive seizures. Kindling induced widespread increases in non-AD-generating stimulation response and ipsilateral functional connectivity and elevated anxiety. Individual seizures in kindled animals showed more signif

SUBMITTER: Choy M 

PROVIDER: S-EPMC10402913 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature